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Metabolic management of microenvironment acidity in glioblastoma
Glioblastoma (GBM), similar to most cancers, is dependent on fermentation metabolism for the synthesis of biomass and energy (ATP) regardless of the cellular or genetic heterogeneity seen within the tumor. The transition from respiration to fermentation arises from the documented defects in the numb...
Autores principales: | Seyfried, Thomas N., Arismendi-Morillo, Gabriel, Zuccoli, Giulio, Lee, Derek C., Duraj, Tomas, Elsakka, Ahmed M., Maroon, Joseph C., Mukherjee, Purna, Ta, Linh, Shelton, Laura, D'Agostino, Dominic, Kiebish, Michael, Chinopoulos, Christos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428719/ https://www.ncbi.nlm.nih.gov/pubmed/36059707 http://dx.doi.org/10.3389/fonc.2022.968351 |
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