Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1

The polo-like kinase 1 (Plk1) is an important mediator of cell cycle regulation and a recognized anti-cancer molecular target. In addition to its catalytic kinase domain (KD), Plk1 contains a polo-box domain (PBD), which engages in protein–protein interactions (PPIs) essential to proper Plk1 functio...

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Detalles Bibliográficos
Autores principales: Tsuji, Kohei, Hymel, David, Ma, Buyong, Tamamura, Hirokazu, Nussinov, Ruth, Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428768/
https://www.ncbi.nlm.nih.gov/pubmed/36128509
http://dx.doi.org/10.1039/d2cb00153e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428768/
https://www.ncbi.nlm.nih.gov/pubmed/36128509
http://dx.doi.org/10.1039/d2cb00153e

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