An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor

An essential step in the biosynthesis of polyketide and non-ribosomal peptide natural products is cleavage of the thioester bond that tethers the acyl/peptidyl chain to its biosynthetic enzyme. In modular polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) chain release is typica...

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Detalles Bibliográficos
Autores principales: Little, Rory, Trottmann, Felix, Preissler, Miriam, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428774/
https://www.ncbi.nlm.nih.gov/pubmed/36128506
http://dx.doi.org/10.1039/d2cb00121g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428774/
https://www.ncbi.nlm.nih.gov/pubmed/36128506
http://dx.doi.org/10.1039/d2cb00121g

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