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An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor
An essential step in the biosynthesis of polyketide and non-ribosomal peptide natural products is cleavage of the thioester bond that tethers the acyl/peptidyl chain to its biosynthetic enzyme. In modular polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) chain release is typica...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428774/ https://www.ncbi.nlm.nih.gov/pubmed/36128506 http://dx.doi.org/10.1039/d2cb00121g |