The N-linker region of hERG1a upregulates hERG1b potassium channels

A major physiological role of hERG1 (human Ether-á-go-go-Related Gene 1) potassium channels is to repolarize cardiac action potentials. Two isoforms, hERG1a and hERG1b, associate to form the potassium current I(K)(r) in cardiomyocytes. Inherited mutations in hERG1a or hERG1b cause prolonged cardiac...

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Detalles Bibliográficos
Autores principales: Johnson, Ashley A., Crawford, Taylor R., Trudeau, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428852/
https://www.ncbi.nlm.nih.gov/pubmed/35798139
http://dx.doi.org/10.1016/j.jbc.2022.102233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428852/
https://www.ncbi.nlm.nih.gov/pubmed/35798139
http://dx.doi.org/10.1016/j.jbc.2022.102233

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