An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction

Pyridoxal 5′-phosphate (PLP)-dependent enzymes have been extensively studied for their ability to fine-tune PLP cofactor electronics to promote a wide array of chemistries. Neutron crystallography offers a straightforward approach to studying the electronic states of PLP and the electrostatics of en...

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Detalles Bibliográficos
Autores principales: Drago, Victoria N., Dajnowicz, Steven, Parks, Jerry M., Blakeley, Matthew P., Keen, David A., Coquelle, Nicolas, Weiss, Kevin L., Gerlits, Oksana, Kovalevsky, Andrey, Mueser, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430417/
https://www.ncbi.nlm.nih.gov/pubmed/36128223
http://dx.doi.org/10.1039/d2sc02285k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430417/
https://www.ncbi.nlm.nih.gov/pubmed/36128223
http://dx.doi.org/10.1039/d2sc02285k

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