BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery

The 3C-like protease (3CLpro) of SARS-CoV-2 is an attractive drug target for developing antivirals against SARS-CoV-2. A few small molecule inhibitors of 3CLpro are in clinical trials for COVID-19 treatments, and more inhibitors are under development. One limiting factor for 3CLpro inhibitors develo...

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Detalles Bibliográficos
Autores principales: Hou, Ningke, Peng, Chen, Zhang, Lijing, Zhu, Yuyao, Hu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430692/
https://www.ncbi.nlm.nih.gov/pubmed/35758897
http://dx.doi.org/10.1128/spectrum.02559-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430692/
https://www.ncbi.nlm.nih.gov/pubmed/35758897
http://dx.doi.org/10.1128/spectrum.02559-21

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