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Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza

Influenza A virus (IAV) coopts numerous host factors for efficient replication. The cysteine protease cathepsin W (CTSW) has been identified as one host factor required for IAV entry, specifically for the escape of IAVs from late endosomes. However, the substrate specificity of CTSW and the proviral...

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Detalles Bibliográficos
Autores principales: Günther, Sira C., Martínez-Romero, Carles, Sempere Borau, Milagros, Pham, Christine T. N., García-Sastre, Adolfo, Stertz, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431242/
https://www.ncbi.nlm.nih.gov/pubmed/35867415
http://dx.doi.org/10.1128/spectrum.00921-22