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Concentrative Nucleoside Transporter, CNT, Results in Selective Toxicity of Toyocamycin against Candida albicans

Toyocamycin (TM) is an adenosine-analog antibiotic isolated from Streptomyces toyocaensis. It inhibits Candida albicans, several plant fungal pathogens, and human cells, but many fungi, including Saccharomyces cerevisiae, are much less susceptible to TM. Aiming to clarify why TM and its analogs tube...

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Detalles Bibliográficos
Autores principales: Ojima, Yoshihiro, Yokota, Naoki, Tanibata, Yuki, Nerome, Shinsuke, Azuma, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431476/
https://www.ncbi.nlm.nih.gov/pubmed/35913167
http://dx.doi.org/10.1128/spectrum.01138-22