Comparison of Gene Editing versus a Neutrophil Elastase Inhibitor as Potential Therapies for ELANE Neutropenia

Heterozygous mutations in ELANE, the gene for neutrophil elastase, cause cyclic and congenital neutropenia through the programed cell death of neutrophil progenitors in the bone marrow. Granulocyte colony-stimulating factor is an effective therapy for these diseases, but alternative therapies are ne...

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Detalles Bibliográficos
Autores principales: Makaryan, Vahagn, Kelley, Merideth, Fletcher, Breanna, Archibald, Isabella, Poulsen, Tanoya, Dale, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431957/
https://www.ncbi.nlm.nih.gov/pubmed/36052149
http://dx.doi.org/10.33696/immunology.4.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431957/
https://www.ncbi.nlm.nih.gov/pubmed/36052149
http://dx.doi.org/10.33696/immunology.4.129

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