Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

Some missense gain-of-function mutations in CACNA1C gene, encoding calcium channel Ca(V)1.2, cause a life-threatening form of long QT syndrome named Timothy syndrome, with currently no clinically-effective therapeutics. Here we report that pharmacological targeting of sigma non-opioid intracellular...

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Detalles Bibliográficos
Autores principales: Song, LouJin, Bekdash, Ramsey, Morikawa, Kumi, Quejada, Jose R., Klein, Alison D., Aina-Badejo, Danielle, Yoshida, Kazushige, Yamamoto, Hannah E., Chalan, Amy, Yang, Risako, Patel, Achchhe, Sirabella, Dario, Lee, Teresa M., Joseph, Leroy C., Kawano, Fuun, Warren, Junco S., Soni, Rajesh K., Morrow, John P., Yazawa, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431959/
https://www.ncbi.nlm.nih.gov/pubmed/36051854
http://dx.doi.org/10.1038/s44161-021-00016-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431959/
https://www.ncbi.nlm.nih.gov/pubmed/36051854
http://dx.doi.org/10.1038/s44161-021-00016-2

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