Cargando…

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

Some missense gain-of-function mutations in CACNA1C gene, encoding calcium channel Ca(V)1.2, cause a life-threatening form of long QT syndrome named Timothy syndrome, with currently no clinically-effective therapeutics. Here we report that pharmacological targeting of sigma non-opioid intracellular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, LouJin, Bekdash, Ramsey, Morikawa, Kumi, Quejada, Jose R., Klein, Alison D., Aina-Badejo, Danielle, Yoshida, Kazushige, Yamamoto, Hannah E., Chalan, Amy, Yang, Risako, Patel, Achchhe, Sirabella, Dario, Lee, Teresa M., Joseph, Leroy C., Kawano, Fuun, Warren, Junco S., Soni, Rajesh K., Morrow, John P., Yazawa, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431959/ https://www.ncbi.nlm.nih.gov/pubmed/36051854 http://dx.doi.org/10.1038/s44161-021-00016-2

Ejemplares similares

GEM-IL: A highly responsive fluorescent lactate indicator
por: Bekdash, Ramsey, et al.
Publicado: (2021)

Advanced maturation of human cardiac tissue grown from pluripotent stem cells
por: Ronaldson-Bouchard, Kacey, et al.
Publicado: (2018)

Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome
por: Song, LouJin, et al.
Publicado: (2017)

Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1
por: Quejada, Jose R., et al.
Publicado: (2017)

Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
por: Morikawa, Kumi, et al.
Publicado: (2020)

Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity
por: Iannello, Grazia, et al.
Publicado: (2021)

Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL
por: Iannello, Grazia, et al.
Publicado: (2022)

Fluorescence Imaging-Based High-Throughput Screening of Fast- and Slow-Cycling LOV Proteins
por: Kawano, Fuun, et al.
Publicado: (2013)

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome
por: Seethala, Srikanth, et al.
Publicado: (2015)

An asymptotically free chiral linear sigma model with quarks coupled to gluons
por: Soni, V
Publicado: (1994)

Visual six sigma: making data analysis lean
por: Cox, Ian, et al.
Publicado: (2016)

On the width of SIGMA hypernuclei and SIGMA- atoms
por: Brockmann, R, et al.
Publicado: (1982)

Sum rules for $\SIGMA\SIGMA$ (In Russian)
por: Fil'kov, L V, et al.
Publicado: (1970)

Long QT molecular autopsy in sudden infant death syndrome
por: Glengarry, Joanna Moira, et al.
Publicado: (2014)

$\Sigma^{+}$, $\Sigma^{0}$ and $\Sigma^{-}$ hyperon production in hadronic $Z^{0}$ decays
por: Alexander, Gideon, et al.
Publicado: (1996)

Is the nonlinear sigma model the m$_{sigma}$ --> $\infty$ limit of the linear sigma model?
por: Chan, L H
Publicado: (1987)

Sigma+, Sigma0 and Sigma- Hyperon Production in Hadronic Z0- Decays
por: CERN. Geneva
Publicado: (1995)

The Book of Qt 4: The Art of Building Qt Applications
por: Molkentin, Daniel
Publicado: (2007)

Which QT Correction Formulae to Use for QT Monitoring?
por: Vandenberk, Bert, et al.
Publicado: (2016)

Which QT Correction Formulae to Use for QT Monitoring?
Publicado: (2018)

Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems
por: Yu, Gaigai, et al.
Publicado: (2016)

Sigma-1 Receptor Enhances Neurite Elongation of Cerebellar Granule Neurons via TrkB Signaling
por: Kimura, Yuriko, et al.
Publicado: (2013)

Measurement of the reactions $\overline{p}p \to \overline{\Sigma^{+}} \Sigma^{+}$ and $\overline{p}p \to \overline{\Sigma^{-}}\Sigma^{-}$ close to threshold
por: Barnes, P D, et al.
Publicado: (1997)

Qt for Symbian
por: Fitzek, Frank H P, et al.
Publicado: (2009)

Programming with Qt
por: Dalheimer, Matthias Kalle
Publicado: (1999)

Programming with Qt
por: Dalheimer, Matthias Kalle
Publicado: (2002)

Information transfer in QT-RR dynamics: Application to QT-correction
por: Potapov, Ilya, et al.
Publicado: (2018)

Manual vs. automatic assessment of the QT-interval and corrected QT
por: Neumann, Benjamin, et al.
Publicado: (2023)

A new determination of the capture ratio : $\gamma$ 0 = $\sigma^{-}$ p -> $\sigma^{0}$ n / ( $\sigma^{-}$ p -> $\sigma^{0}$ n ) + ( $\sigma^{-}$ p -> $\lambda^{0}$ n )
por: Hepp, V, et al.
Publicado: (1968)

Energy behaviour of sigma$_{tot}$, sigma$_{el}$, sigma$_{diff}$ and rho in the perturbative Reggeon calculus
por: Innocente, Vincenzo, et al.
Publicado: (1987)

Hard meson calculation of sigma pi pi , A sigma pi and sigma AA vertices
por: Kleinert, H, et al.
Publicado: (1972)

Protein level identification of the Listeria monocytogenes Sigma H, Sigma L, and Sigma C regulons
por: Mujahid, Sana, et al.
Publicado: (2013)

Pion, sigma and nucleon propagators in the linear $\sigma$-model
por: Flego, S P, et al.
Publicado: (1995)

First evidence for $\Sigma_{b}$ and $\Sigma_{b}*$ baryons
por: Feindt, Michael, et al.
Publicado: (1995)

The Sigma Enigma: A Narrative Review of Sigma Receptors
por: Pergolizzi, Joseph, et al.
Publicado: (2023)

Mastering Qt 5: create stunning cross-platform applications using C++ with Qt widgets and QML with QT Quick
por: Lazar, Guillaume, et al.
Publicado: (2018)

Game programming using Qt 5 beginner's guide: create amazing games with Qt 5, C++, and Qt Quick
por: Strakhov, Pavel, et al.
Publicado: (2018)

Advanced Qt programming: creating great software with C++ and Qt 4
por: Summerfield, Mark
Publicado: (2011)

A Study of QT Interval and QT Dispersion During Laparoscopic Cholecystectomy
por: Parikh, Heena, et al.
Publicado: (2009)

Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ1
por: Sogo, Tatsufumi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9cnoh4227pg7uubno7qpmejdlp