Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity

The accumulation of somatic DNA mutations over time is a hallmark of aging in many dividing and nondividing cells but has not been studied in postmitotic human cardiomyocytes. Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide varian...

Descripción completa

Detalles Bibliográficos
Autores principales: Choudhury, Sangita, Huang, August Yue, Kim, Junho, Zhou, Zinan, Morillo, Katherine, Maury, Eduardo A., Tsai, Jessica W., Miller, Michael B., Lodato, Michael A., Araten, Sarah, Hilal, Nazia, Lee, Eunjung Alice, Chen, Ming Hui, Walsh, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432807/
https://www.ncbi.nlm.nih.gov/pubmed/36051457
http://dx.doi.org/10.1038/s43587-022-00261-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432807/
https://www.ncbi.nlm.nih.gov/pubmed/36051457
http://dx.doi.org/10.1038/s43587-022-00261-5

Ejemplares similares