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A lysosomal regulatory circuit essential for the development and function of microglia

As the primary phagocytic cells of the central nervous system, microglia exquisitely regulate their lysosomal activity to facilitate brain development and homeostasis. However, mechanisms that coordinate lysosomal activity with microglia development, chemotaxis, and function remain unclear. Here, we...

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Detalles Bibliográficos
Autores principales: Iyer, Harini, Shen, Kimberle, Meireles, Ana M., Talbot, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432849/
https://www.ncbi.nlm.nih.gov/pubmed/36044568
http://dx.doi.org/10.1126/sciadv.abp8321