PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

Regulatory T (Treg) cells are central to limit immune responses to allergens. Here we show that PD-L2 deficiency prevents the induction of tolerance to ovalbumin and control of airway hyperreactivity, in particular by limiting pTreg numbers and function. In vitro, PD-1/PD-L2 interactions increase iT...

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Detalles Bibliográficos
Autores principales: Hurrell, Benjamin P., Helou, Doumet Georges, Howard, Emily, Painter, Jacob D., Shafiei-Jahani, Pedram, Sharpe, Arlene H., Akbari, Omid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433378/
https://www.ncbi.nlm.nih.gov/pubmed/36045140
http://dx.doi.org/10.1038/s41467-022-32899-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433378/
https://www.ncbi.nlm.nih.gov/pubmed/36045140
http://dx.doi.org/10.1038/s41467-022-32899-5

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