A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPR(ER) axis

Hypoxic tumor microenvironment (TME) plays critical roles in induction of cancer stem cell-like phenotype in breast cancer and contribute to chemoresistance. However, the mechanism underlying stemness reprogramming of breast cancer cells (BCs) by hypoxic TME remains largely unknown. In the present s...

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Detalles Bibliográficos
Autores principales: Yan, Yuanyuan, He, Miao, Zhao, Lin, Wu, Huizhe, Zhao, Yanyun, Han, Li, Wei, Binbin, Ye, Dongman, Lv, Xuemei, Wang, Yan, Yao, Weifan, Zhao, Haishan, Chen, Bo, Jin, Zining, Wen, Jian, Zhu, Yan, Yu, Tao, Jin, Feng, Wei, Minjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433403/
https://www.ncbi.nlm.nih.gov/pubmed/35301432
http://dx.doi.org/10.1038/s41418-022-00963-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433403/
https://www.ncbi.nlm.nih.gov/pubmed/35301432
http://dx.doi.org/10.1038/s41418-022-00963-8

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