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Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F(1) subcomplex

Mitochondrial ATP synthase is vital not only for cellular energy production but also for energy dissipation and cell death. ATP synthase c-ring was suggested to house the leak channel of mitochondrial permeability transition (mPT), which activates during excitotoxic ischemic insult. In this present...

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Detalles Bibliográficos
Autores principales: Mnatsakanyan, Nelli, Park, Han-A, Wu, Jing, He, Xiang, Llaguno, Marc C., Latta, Maria, Miranda, Paige, Murtishi, Besnik, Graham, Morven, Weber, Joachim, Levy, Richard J., Pavlov, Evgeny V., Jonas, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433415/
https://www.ncbi.nlm.nih.gov/pubmed/35322203
http://dx.doi.org/10.1038/s41418-022-00972-7