Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations

Epidermal growth factor receptor (EGFR) is essential for normal cellular functions. Mutations of EGFR’s kinase domain can cause dysregulation leading to non-small cell lung cancer (NSCLC). Exon 20 insertion (ex20ins) mutations in EGFR are one of the leading contributors to oncogenesis and confer ins...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Lam, Daniel, Yang, Jeffrey, Hu, Longqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433531/
https://www.ncbi.nlm.nih.gov/pubmed/36065226
http://dx.doi.org/10.1007/s00044-022-02952-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433531/
https://www.ncbi.nlm.nih.gov/pubmed/36065226
http://dx.doi.org/10.1007/s00044-022-02952-5

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