Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

Transposable elements (TEs) are widespread genetic parasites known to be kept under tight transcriptional control. Here, we describe a functional connection between the mouse-orthologous “nuclear exosome targeting” (NEXT) and “human silencing hub” (HUSH) complexes, involved in nuclear RNA decay and...

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Detalles Bibliográficos
Autores principales: Garland, William, Müller, Iris, Wu, Mengjun, Schmid, Manfred, Imamura, Katsutoshi, Rib, Leonor, Sandelin, Albin, Helin, Kristian, Jensen, Torben Heick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433625/
https://www.ncbi.nlm.nih.gov/pubmed/35349793
http://dx.doi.org/10.1016/j.molcel.2022.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433625/
https://www.ncbi.nlm.nih.gov/pubmed/35349793
http://dx.doi.org/10.1016/j.molcel.2022.03.004

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