Metabolic clearance of select opioids and opioid antagonists using hepatic spheroids and recombinant cytochrome P450 enzymes

The opioid crisis is a pressing public health issue, exacerbated by the emergence of more potent synthetic opioids, particularly fentanyl and its analogs. While competitive antagonists exist, their efficacy against synthetic opioids is largely unknown. Furthermore, due to the short durations of acti...

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Detalles Bibliográficos
Autores principales: Tuet, Wing Y., Pierce, Samuel A., Conroy, Matthieu, Vignola, Justin N., Tressler, Justin, diTargiani, Robert C., McCranor, Bryan J., Wong, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Invited Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433823/
https://www.ncbi.nlm.nih.gov/pubmed/36045607
http://dx.doi.org/10.1002/prp2.1000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433823/
https://www.ncbi.nlm.nih.gov/pubmed/36045607
http://dx.doi.org/10.1002/prp2.1000

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