β-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice

STUDY QUESTION: What is the effect of the ketone β-hydroxybutyrate (βOHB) on preimplantation mouse embryo development, metabolism, epigenetics and post-transfer viability? SUMMARY ANSWER: In vitro βOHB exposure at ketogenic diet (KD)-relevant serum concentrations significantly impaired preimplantati...

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Detalles Bibliográficos
Autores principales: Whatley, Emma G, Truong, Thi T, Wilhelm, Dagmar, Harvey, Alexandra J, Gardner, David K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433850/
https://www.ncbi.nlm.nih.gov/pubmed/35856159
http://dx.doi.org/10.1093/humrep/deac153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433850/
https://www.ncbi.nlm.nih.gov/pubmed/35856159
http://dx.doi.org/10.1093/humrep/deac153

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