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Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets
Organoids enable in vitro modeling of complex developmental processes and disease pathologies. Like most 3D cultures, organoids lack sufficient oxygen supply and therefore experience cellular stress. These negative effects are particularly prominent in complex models, such as brain organoids, and ca...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433936/ https://www.ncbi.nlm.nih.gov/pubmed/35919947 http://dx.doi.org/10.15252/embj.2022111118 |