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The prion-like transmission of tau oligomers via exosomes
The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggre...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434014/ https://www.ncbi.nlm.nih.gov/pubmed/36062141 http://dx.doi.org/10.3389/fnagi.2022.974414 |
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author | Jackson, Noel A. Guerrero-Muñoz, Marcos J. Castillo-Carranza, Diana L. |
author_facet | Jackson, Noel A. Guerrero-Muñoz, Marcos J. Castillo-Carranza, Diana L. |
author_sort | Jackson, Noel A. |
collection | PubMed |
description | The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggregate. During the progression of the disease, misfolded tau polymerizes into oligomers and intracellular neurofibrillary tangles (NFTs). While the toxicity of NFTs is an ongoing debate, the contribution of tau oligomers to early onset neurodegenerative pathogenesis is accepted. Tau oligomers are readily transferred from neuron to neuron propagating through the brain inducing neurodegeneration. Recently, transmission of tau oligomers via exosomes is now proposed. There is still too much to uncover about tau misfolding and propagation. Here we summarize novel findings of tau oligomers transmission and propagation via exosomes. |
format | Online Article Text |
id | pubmed-9434014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94340142022-09-02 The prion-like transmission of tau oligomers via exosomes Jackson, Noel A. Guerrero-Muñoz, Marcos J. Castillo-Carranza, Diana L. Front Aging Neurosci Aging Neuroscience The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggregate. During the progression of the disease, misfolded tau polymerizes into oligomers and intracellular neurofibrillary tangles (NFTs). While the toxicity of NFTs is an ongoing debate, the contribution of tau oligomers to early onset neurodegenerative pathogenesis is accepted. Tau oligomers are readily transferred from neuron to neuron propagating through the brain inducing neurodegeneration. Recently, transmission of tau oligomers via exosomes is now proposed. There is still too much to uncover about tau misfolding and propagation. Here we summarize novel findings of tau oligomers transmission and propagation via exosomes. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9434014/ /pubmed/36062141 http://dx.doi.org/10.3389/fnagi.2022.974414 Text en Copyright © 2022 Jackson, Guerrero-Muñoz and Castillo-Carranza. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Jackson, Noel A. Guerrero-Muñoz, Marcos J. Castillo-Carranza, Diana L. The prion-like transmission of tau oligomers via exosomes |
title | The prion-like transmission of tau oligomers via exosomes |
title_full | The prion-like transmission of tau oligomers via exosomes |
title_fullStr | The prion-like transmission of tau oligomers via exosomes |
title_full_unstemmed | The prion-like transmission of tau oligomers via exosomes |
title_short | The prion-like transmission of tau oligomers via exosomes |
title_sort | prion-like transmission of tau oligomers via exosomes |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434014/ https://www.ncbi.nlm.nih.gov/pubmed/36062141 http://dx.doi.org/10.3389/fnagi.2022.974414 |
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