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Methamphetamine signals transcription of IL1β and TNFα in a reactive oxygen species-dependent manner and interacts with HIV-1 Tat to decrease antioxidant defense mechanisms

Methamphetamine (Meth) abuse is a common HIV co-morbidity that is linked to aggravated Central Nervous System (CNS) inflammation, which accentuates HIV- associated neurological disorders, triggered both directly or indirectly by the drug. We used the well-established human innate immune macrophage c...

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Detalles Bibliográficos
Autores principales: Basova, Liana V., Vien, Whitney, Bortell, Nikki, Najera, Julia A., Marcondes, Maria Cecilia Garibaldi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434488/
https://www.ncbi.nlm.nih.gov/pubmed/36060276
http://dx.doi.org/10.3389/fncel.2022.911060