Cargando…

Ambra1 deficiency impairs mitophagy in skeletal muscle

BACKGROUND: Maintaining healthy mitochondria is mandatory for muscle viability and function. An essential surveillance mechanism targeting defective and harmful mitochondria to degradation is the selective form of autophagy called mitophagy. Ambra1 is a multifaceted protein with well‐known autophagi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gambarotto, Lisa, Metti, Samuele, Chrisam, Martina, Cerqua, Cristina, Sabatelli, Patrizia, Armani, Andrea, Zanon, Carlo, Spizzotin, Marianna, Castagnaro, Silvia, Strappazzon, Flavie, Grumati, Paolo, Cescon, Matilde, Braghetta, Paola, Trevisson, Eva, Cecconi, Francesco, Bonaldo, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434724/ https://www.ncbi.nlm.nih.gov/pubmed/35593053 http://dx.doi.org/10.1002/jcsm.13010

Ejemplares similares

Extracellular Collagen VI Has Prosurvival and Autophagy Instructive Properties in Mouse Fibroblasts
por: Castagnaro, Silvia, et al.
Publicado: (2018)

Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development
por: Skobo, Tatjana, et al.
Publicado: (2014)

AMBRA1-induced mitophagy: A new mechanism to cope with cancer?
por: Strappazzon, Flavie, et al.
Publicado: (2015)

The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction
por: Metti, Samuele, et al.
Publicado: (2020)

Corrigendum: The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction
por: Metti, Samuele, et al.
Publicado: (2021)

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
por: Di Rita, Anthea, et al.
Publicado: (2018)

Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice
por: Chrisam, Martina, et al.
Publicado: (2015)

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction
por: Fontana, Camilla Maria, et al.
Publicado: (2023)

Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis
por: Strappazzon, Flavie, et al.
Publicado: (2016)

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
por: Strappazzon, F, et al.
Publicado: (2015)

Collagen VI in healthy and diseased nervous system
por: Gregorio, Ilaria, et al.
Publicado: (2018)

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
por: Di Rita, Anthea, et al.
Publicado: (2018)

Lack of collagen VI promotes neurodegeneration by impairing autophagy and inducing apoptosis during aging
por: Cescon, Matilde, et al.
Publicado: (2016)

Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial
por: Castagnaro, Silvia, et al.
Publicado: (2016)

Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice
por: Spitali, Pietro, et al.
Publicado: (2013)

AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation
por: Faienza, Fiorella, et al.
Publicado: (2023)

Aggresome–Autophagy Involvement in a Sarcopenic Patient with Rigid Spine Syndrome and a p.C150R Mutation in FHL1 Gene
por: Sabatelli, Patrizia, et al.
Publicado: (2014)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Reversible induction of mitophagy by an optogenetic bimodular system
por: D’Acunzo, Pasquale, et al.
Publicado: (2019)

Connecting autophagy: AMBRA1 and its network of regulation
por: Cianfanelli, Valentina, et al.
Publicado: (2015)

Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies
por: Grumati, Paolo, et al.
Publicado: (2012)

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation
por: Nazio, Francesca, et al.
Publicado: (2016)

Ambra Grisea
por: Still, Horace
Publicado: (1888)

Changes in Muscle Cell Metabolism and Mechanotransduction Are Associated with Myopathic Phenotype in a Mouse Model of Collagen VI Deficiency
por: De Palma, Sara, et al.
Publicado: (2013)

AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability
por: Di Rienzo, Martina, et al.
Publicado: (2021)

Collagen VI sustains cell stemness and chemotherapy resistance in glioblastoma
por: Cescon, Matilde, et al.
Publicado: (2023)

Loss of Ambra1 promotes melanoma growth and invasion
por: Di Leo, Luca, et al.
Publicado: (2021)

Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression
por: Pourpirali, Somayeh, et al.
Publicado: (2015)

The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone
por: Yazdankhah, M, et al.
Publicado: (2014)

Correction: Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development
Publicado: (2014)

Ambra1 Is an Essential Regulator of Autophagy and Apoptosis in SW620 Cells: Pro-Survival Role of Ambra1
por: Gu, Wen, et al.
Publicado: (2014)

Sexual dimorphism of AMBRA1-related autistic features in human and mouse
por: Mitjans, M, et al.
Publicado: (2017)

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
por: Di Bartolomeo, Sabrina, et al.
Publicado: (2010)

Ambra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders
por: Nobili, Annalisa, et al.
Publicado: (2018)

Identification of a deep intronic mutation in the COL6A2 gene by a novel custom oligonucleotide CGH array designed to explore allelic and genetic heterogeneity in collagen VI-related myopathies
por: Bovolenta, Matteo, et al.
Publicado: (2010)

The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma
por: Tiberti, Matteo, et al.
Publicado: (2022)

Collagen VI deficiency causes behavioral abnormalities and cortical dopaminergic dysfunction
por: Gregorio, Ilaria, et al.
Publicado: (2022)

Cyclosporine A in Ullrich Congenital Muscular Dystrophy: Long-Term Results
por: Merlini, Luciano, et al.
Publicado: (2011)

Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
por: Frias, Alex, et al.
Publicado: (2023)

Ambras Syndrome with Gingival Hyperplasia: A Rare Entity
por: Reddy Kundoor, Vinay Kumar, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3slf7a532bitl09okklr7igkkj