Resistance Evolution against Host-directed Antiviral Agents: Buffalopox Virus Switches to Use p38-ϒ under Long-term Selective Pressure of an Inhibitor Targeting p38-α

Host-dependency factors have increasingly been targeted to minimize antiviral drug resistance. In this study, we have demonstrated that inhibition of p38 mitogen-activated protein kinase (a cellular protein) suppresses buffalopox virus (BPXV) protein synthesis by targeting p38-MNK1-eIF4E signaling p...

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Detalles Bibliográficos
Autores principales: Chander, Yogesh, Kumar, Ram, Verma, Assim, Khandelwal, Nitin, Nagori, Himanshu, Singh, Namita, Sharma, Shalini, Pal, Yash, Puvar, Apurvasinh, Pandit, Rameshchandra, Shukla, Nitin, Chavada, Priyank, Tripathi, Bhupendra N, Barua, Sanjay, Kumar, Naveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435063/
https://www.ncbi.nlm.nih.gov/pubmed/35975687
http://dx.doi.org/10.1093/molbev/msac177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435063/
https://www.ncbi.nlm.nih.gov/pubmed/35975687
http://dx.doi.org/10.1093/molbev/msac177

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