Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain

The Omicron variant of SARS-CoV-2 evades neutralization by most serum antibodies elicited by two doses of mRNA vaccines, but a third dose of the same vaccine increases anti-Omicron neutralizing antibodies. By combining computational modeling with data from vaccinated humans we reveal mechanisms unde...

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Detalles Bibliográficos
Autores principales: Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., Chakraborty, Arup K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435403/
https://www.ncbi.nlm.nih.gov/pubmed/36052368
http://dx.doi.org/10.1101/2022.08.24.505127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435403/
https://www.ncbi.nlm.nih.gov/pubmed/36052368
http://dx.doi.org/10.1101/2022.08.24.505127

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