Cargando…

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A

The affinity and thermodynamic parameters for the interactions of two naturally occurring neurotoxins, (+)-anatoxin-a and (−)-hosieine-A, with acetylcholine-binding protein were investigated using a fluorescence-quenching assay and isothermal titration calorimetry. The crystal structures of their co...

Descripción completa

Detalles Bibliográficos
Autores principales: Parker, Holly P., Dawson, Alice, Jones, Mathew J., Yan, Rui, Ouyang, Jie, Hong, Ran, Hunter, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435674/
https://www.ncbi.nlm.nih.gov/pubmed/36048081
http://dx.doi.org/10.1107/S2053230X22007762