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Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A

The affinity and thermodynamic parameters for the interactions of two naturally occurring neurotoxins, (+)-anatoxin-a and (−)-hosieine-A, with acetylcholine-binding protein were investigated using a fluorescence-quenching assay and isothermal titration calorimetry. The crystal structures of their co...

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Detalles Bibliográficos
Autores principales:	Parker, Holly P., Dawson, Alice, Jones, Mathew J., Yan, Rui, Ouyang, Jie, Hong, Ran, Hunter, William N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2022
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435674/ https://www.ncbi.nlm.nih.gov/pubmed/36048081 http://dx.doi.org/10.1107/S2053230X22007762

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