Cargando…

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A

The affinity and thermodynamic parameters for the interactions of two naturally occurring neurotoxins, (+)-anatoxin-a and (−)-hosieine-A, with acetylcholine-binding protein were investigated using a fluorescence-quenching assay and isothermal titration calorimetry. The crystal structures of their co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parker, Holly P., Dawson, Alice, Jones, Mathew J., Yan, Rui, Ouyang, Jie, Hong, Ran, Hunter, William N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2022
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435674/ https://www.ncbi.nlm.nih.gov/pubmed/36048081 http://dx.doi.org/10.1107/S2053230X22007762

Ejemplares similares

The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors
por: Wonnacott, Susan, et al.
Publicado: (2006)

Interactions between 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors
por: Bueno, Renata V., et al.
Publicado: (2022)

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors
por: Wall, Teagan R., et al.
Publicado: (2017)

The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
por: Williams, Dustin K., et al.
Publicado: (2011)

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
por: Marquart, Leanna A., et al.
Publicado: (2019)

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
por: Schapira, Matthieu, et al.
Publicado: (2002)

Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
por: Galle-Treger, Lauriane, et al.
Publicado: (2016)

Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine
por: Andrud, Kristin, et al.
Publicado: (2019)

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein
por: Dawson, Alice, et al.
Publicado: (2019)

Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions
por: Alexandris, Nikolaos, et al.
Publicado: (2020)

Substitution of D-Arginine at Position 11 of α-RgIA Potently Inhibits α7 Nicotinic Acetylcholine Receptor
por: Wu, Yong, et al.
Publicado: (2023)

The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist
por: Hu, Yan, et al.
Publicado: (2009)

Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors
por: Marotta, Christopher B., et al.
Publicado: (2014)

Insight into the Binding Mode of Agonists of the Nicotinic Acetylcholine Receptor from Calculated Electron Densities
por: Beck, Michael E, et al.
Publicado: (2015)

Phosphocholine – an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors
por: Richter, K., et al.
Publicado: (2016)

Nicotinic acetylcholine receptors and cancer
por: DANG, NINGNING, et al.
Publicado: (2016)

Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine
por: Ren, Zuo Jun, et al.
Publicado: (2015)

The SARS-CoV-2 Virus and the Cholinergic System: Spike Protein Interaction with Human Nicotinic Acetylcholine Receptors and the Nicotinic Agonist Varenicline
por: Carlson, Eric C., et al.
Publicado: (2023)

Partial nicotinic acetylcholine (α4β2) agonists as promising new medications for smoking cessation
por: Singh, J., et al.
Publicado: (2008)

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors
por: Gill, JasKiran K., et al.
Publicado: (2013)

The Oncogenic Functions of Nicotinic Acetylcholine Receptors
por: Zhao, Yue
Publicado: (2016)

Nicotinic acetylcholine receptors modulate osteoclastogenesis
por: Mandl, Peter, et al.
Publicado: (2016)

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
por: Zoli, Michele, et al.
Publicado: (2018)

Evolution of vertebrate nicotinic acetylcholine receptors
por: Pedersen, Julia E., et al.
Publicado: (2019)

Nicotinic Acetylcholine Receptors in the Respiratory Tract
por: Hollenhorst, Monika I., et al.
Publicado: (2021)

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors
por: Couesnon, Aurélie, et al.
Publicado: (2016)

(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors
por: Richards, David P., et al.
Publicado: (2022)

Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors
por: Olsen, Jeppe A., et al.
Publicado: (2014)

Pathogenesis of Abdominal Aortic Aneurysms: Role of Nicotine and Nicotinic Acetylcholine Receptors
por: Li, Zong-Zhuang, et al.
Publicado: (2012)

Nicotinic Acetylcholine Receptor Agonists Attenuate Septic Acute Kidney Injury in Mice by Suppressing Inflammation and Proteasome Activity
por: Chatterjee, Prodyot K., et al.
Publicado: (2012)

Agonist and antagonist effects of tobacco-related nitrosamines on human α4β2 nicotinic acetylcholine receptors
por: Brusco, Simone, et al.
Publicado: (2015)

Differential Modulation of GABA(A) and NMDA Receptors by an α7-nicotinic Acetylcholine Receptor Agonist in Chronic Glaucoma
por: Zhou, Xujiao, et al.
Publicado: (2017)

A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE
por: Godin, Jean-Rémi, et al.
Publicado: (2019)

Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages
por: Tan, Yao, et al.
Publicado: (2022)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI
por: Deba, Farah, et al.
Publicado: (2021)

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
por: Smith, Marci L., et al.
Publicado: (2014)

Cocaine potently blocks neuronal α(3)β(4) nicotinic acetylcholine receptors in SH-SY5Y cells
por: Ma, Ze-gang, et al.
Publicado: (2019)

A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily
por: Luo, Sulan, et al.
Publicado: (2013)

The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms
por: Hansen, Tina V. A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jhprtb7nh2si3eit6lq3lqqfv7