A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer’s disease, leads to blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction predicts cognitive decline and precedes synaptic deficits in APOE4 human carriers. How APOE4 affects BBB and synaptic function...

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Detalles Bibliográficos
Autores principales: Barisano, Giuseppe, Kisler, Kassandra, Wilkinson, Brent, Nikolakopoulou, Angeliki Maria, Sagare, Abhay P., Wang, Yaoming, Gilliam, William, Huuskonen, Mikko T., Hung, Shu-Ting, Ichida, Justin K., Gao, Fan, Coba, Marcelo P., Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435921/
https://www.ncbi.nlm.nih.gov/pubmed/36040482
http://dx.doi.org/10.1084/jem.20221137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435921/
https://www.ncbi.nlm.nih.gov/pubmed/36040482
http://dx.doi.org/10.1084/jem.20221137

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