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Multicolor fluorescence activated cell sorting to generate humanized monoclonal antibody binding seven subtypes of BoNT/F

Generating specific monoclonal antibodies (mAbs) that neutralize multiple antigen variants is challenging. Here, we present a strategy to generate mAbs that bind seven subtypes of botulinum neurotoxin serotype F (BoNT/F) that differ from each other in amino acid sequence by up to 36%. Previously, we...

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Detalles Bibliográficos
Autores principales:	Fan, Yongfeng, Sun, Zhengda, Conrad, Fraser, Wen, Weihua, Zhao, Lequn, Lou, Jianlong, Zhou, Yu, Farr-Jones, Shauna, Marks, James D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436041/ https://www.ncbi.nlm.nih.gov/pubmed/36048906 http://dx.doi.org/10.1371/journal.pone.0273512

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