Cargando…
Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease
For Alzheimer’s disease–a leading cause of dementia and global morbidity–improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs. Here, we tested the hypothesis that a polygenic predictor of risk for Alzheimer’s dis...
Autores principales: | Paranjpe, Manish D., Chaffin, Mark, Zahid, Sohail, Ritchie, Scott, Rotter, Jerome I., Rich, Stephen S., Gerszten, Robert, Guo, Xiuqing, Heckbert, Susan, Tracy, Russ, Danesh, John, Lander, Eric S., Inouye, Michael, Kathiresan, Sekar, Butterworth, Adam S., Khera, Amit V. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436054/ https://www.ncbi.nlm.nih.gov/pubmed/36048760 http://dx.doi.org/10.1371/journal.pgen.1010294 |
Ejemplares similares
-
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
por: Ritchie, Scott C., et al.
Publicado: (2021) -
Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank
por: Patel, Aniruddh P., et al.
Publicado: (2020) -
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
por: Khera, Amit V., et al.
Publicado: (2018) -
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
por: Pirruccello, James P., et al.
Publicado: (2020) -
Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease
por: Xu, Yu, et al.
Publicado: (2022)