The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia

Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be due to a...

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Detalles Bibliográficos
Autores principales: Brito da Silva, Anderson, Pennifold, Jane, Henley, Ben, Chatterjee, Koustav, Bateman, David, Whittaker, Roger W., Joshi, Abhijit, Kumar, Hrishikesh, Nicholson, Claire, Baker, Mark R., Greenhill, Stuart D., Walsh, Richard, Seri, Stefano, Jones, Roland S. G., Woodhall, Gavin L., Cunningham, Mark O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436284/
https://www.ncbi.nlm.nih.gov/pubmed/34653311
http://dx.doi.org/10.1002/epi4.12549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436284/
https://www.ncbi.nlm.nih.gov/pubmed/34653311
http://dx.doi.org/10.1002/epi4.12549

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