Cargando…

The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia

Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be due to a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brito da Silva, Anderson, Pennifold, Jane, Henley, Ben, Chatterjee, Koustav, Bateman, David, Whittaker, Roger W., Joshi, Abhijit, Kumar, Hrishikesh, Nicholson, Claire, Baker, Mark R., Greenhill, Stuart D., Walsh, Richard, Seri, Stefano, Jones, Roland S. G., Woodhall, Gavin L., Cunningham, Mark O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Short Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436284/ https://www.ncbi.nlm.nih.gov/pubmed/34653311 http://dx.doi.org/10.1002/epi4.12549

Ejemplares similares

Therapeutic potential of AMPA receptor antagonist perampanel against cerebral ischemia: beyond epileptic disorder
por: Suda, Satoshi, et al.
Publicado: (2019)

Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons
por: Chen, Chao-Yin, et al.
Publicado: (2014)

AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro
por: Lange, Falko, et al.
Publicado: (2019)

Psychiatric and behavioral adverse events in randomized clinical studies of the noncompetitive AMPA receptor antagonist perampanel
por: Ettinger, Alan B., et al.
Publicado: (2015)

Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition
por: Wright, Sukhvir K., et al.
Publicado: (2020)

PTEN Is Required for The Anti-Epileptic Effects of AMPA Receptor Antagonists in Chronic Epileptic Rats
por: Kim, Ji-Eun, et al.
Publicado: (2020)

SERS Detection of the Anti-Epileptic Drug Perampanel in Human Saliva
por: Tommasini, Matteo, et al.
Publicado: (2023)

Efficacy of perampanel as an adjunctive therapy in pediatric focal epilepsy
por: Zhang, Wei-Ran, et al.
Publicado: (2023)

Sirolimus for epileptic seizures associated with focal cortical dysplasia type II
por: Kato, Mitsuhiro, et al.
Publicado: (2022)

Effect of perampanel, a novel AMPA antagonist, on benzodiazepine-resistant status epilepticus in a lithium-pilocarpine rat model
por: Hanada, Takahisa, et al.
Publicado: (2014)

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice
por: Akamatsu, Megumi, et al.
Publicado: (2016)

The Novel Direct Modulatory Effects of Perampanel, an Antagonist of AMPA Receptors, on Voltage-Gated Sodium and M-type Potassium Currents
por: Lai, Ming-Chi, et al.
Publicado: (2019)

Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam
por: Zolkowska, Dorota, et al.
Publicado: (2021)

The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
por: Perversi, Fabio, et al.
Publicado: (2023)

Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates
por: Macrelli, Andrea, et al.
Publicado: (2021)

Bridging Development and Disruption: Comprehensive Insights into Focal Cortical Dysplasia and Epileptic Management
por: Mohsin, Syed Naveed, et al.
Publicado: (2023)

Perampanel for focal epilepsy: insights from early clinical experience
por: Trinka, E., et al.
Publicado: (2015)

Effectiveness and tolerability of perampanel monotherapy in children with newly diagnosed focal epilepsy
por: Zhao, Fen, et al.
Publicado: (2023)

Epileptic Networks in Focal Cortical Dysplasia Revealed Using Electroencephalography–Functional Magnetic Resonance Imaging
por: Thornton, Rachel, et al.
Publicado: (2011)

First add‐on perampanel for focal‐onset seizures: An open‐label, prospective study
por: Kim, Ji Hyun, et al.
Publicado: (2019)

Different pharmacoresistance of focal epileptic spasms, generalized epileptic spasms, and generalized epileptic spasms combined with focal seizures
por: Takahashi, Yukitoshi, et al.
Publicado: (2021)

Deregulation of Astroglial TASK-1 K(+) Channel Decreases the Responsiveness to Perampanel-Induced AMPA Receptor Inhibition in Chronic Epilepsy Rats
por: Lee, Duk-Shin, et al.
Publicado: (2023)

Neurosteroids and Focal Epileptic Disorders
por: Lévesque, Maxime, et al.
Publicado: (2020)

Perampanel and pregnancy
por: Vazquez, Blanca, et al.
Publicado: (2021)

Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies
por: Kwan, Patrick, et al.
Publicado: (2017)

Clinical Experience with Perampanel in Intractable Focal Epilepsy Over 12 Months of Follow-Up
por: Kim, Soo Yeon, et al.
Publicado: (2018)

An Evidence-Based Review On The Use Of Perampanel For The Treatment Of Focal-Onset Seizures In Pediatric Patients
por: Dozières-Puyravel, Blandine, et al.
Publicado: (2019)

Slowed Movement Stopping in Parkinson’s Disease and Focal Dystonia is Improved by Standard Treatment
por: Choudhury, Supriyo, et al.
Publicado: (2019)

Perampanel Affects Up-Stream Regulatory Signaling Pathways of GluA1 Phosphorylation in Normal and Epileptic Rats
por: Kim, Ji-Eun, et al.
Publicado: (2019)

Broadband-NIRS System Identifies Epileptic Focus in a Child with Focal Cortical Dysplasia—A Case Study
por: Vezyroglou, Aikaterini, et al.
Publicado: (2022)

Efficacy and Safety of Perampanel in Children with Drug-Resistant Focal-Onset Seizures: A Retrospective Review
por: Elmardenly, Ahmed, et al.
Publicado: (2023)

Comparison of the effectiveness and safety of perampanel and oxcarbazepine as monotherapy in children and adolescents with newly diagnosed focal epilepsy
por: Yi, Jia-Qin, et al.
Publicado: (2023)

SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model
por: Li, Rong, et al.
Publicado: (2020)

Bottom-of-sulcus dysplasia: the role of (18)F-FDG PET in identifying a focal surgically remedial epileptic lesion
por: Berlangieri, S. U., et al.
Publicado: (2020)

Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients
por: Szekeres-Paraczky, Cecília, et al.
Publicado: (2022)

Efficacy and Tolerability of Perampanel as Adjunctive Therapy in Chinese Patients With Focal-Onset Seizures: An Observational, Prospective Study
por: Zhang, Ranran, et al.
Publicado: (2021)

Cost-effectiveness of perampanel as an adjunctive treatment for uncontrolled focal seizures in pediatric patients: a Chinese perspective
por: Hu, Yani, et al.
Publicado: (2022)

Effectiveness of perampanel in the treatment of pediatric patients with focal epilepsy and ESES: A single-center retrospective study
por: Yu, Tao, et al.
Publicado: (2022)

Corrigendum: Comparison of the effectiveness and safety of perampanel and oxcarbazepine as monotherapy in children and adolescents with newly diagnosed focal epilepsy
por: Yi, Jia-Qin, et al.
Publicado: (2023)

Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients
por: Sun, Yuqiang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jo7eppo6qeiuuh1e2407j6to6d