Malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification

Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of Plasmodium QC. We show that sporozoites of QC-null mutants of rodent and human malaria parasites are rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolli, Surendra Kumar, Molina-Cruz, Alvaro, Araki, Tamasa, Geurten, Fiona J. A., Ramesar, Jai, Chevalley-Maurel, Severine, Kroeze, Hans J., Bezemer, Sascha, de Korne, Clarize, Withers, Roxanne, Raytselis, Nadia, El Hebieshy, Angela F., Kim, Robbert Q., Child, Matthew A., Kakuta, Soichiro, Hisaeda, Hajime, Kobayashi, Hirotaka, Annoura, Takeshi, Hensbergen, Paul J., Franke-Fayard, Blandine M., Barillas-Mury, Carolina, Scheeren, Ferenc A., Janse, Chris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436314/
https://www.ncbi.nlm.nih.gov/pubmed/35994647
http://dx.doi.org/10.1073/pnas.2209729119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436314/
https://www.ncbi.nlm.nih.gov/pubmed/35994647
http://dx.doi.org/10.1073/pnas.2209729119

Ejemplares similares