Cargando…

Malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification

Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of Plasmodium QC. We show that sporozoites of QC-null mutants of rodent and human malaria parasites are rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kolli, Surendra Kumar, Molina-Cruz, Alvaro, Araki, Tamasa, Geurten, Fiona J. A., Ramesar, Jai, Chevalley-Maurel, Severine, Kroeze, Hans J., Bezemer, Sascha, de Korne, Clarize, Withers, Roxanne, Raytselis, Nadia, El Hebieshy, Angela F., Kim, Robbert Q., Child, Matthew A., Kakuta, Soichiro, Hisaeda, Hajime, Kobayashi, Hirotaka, Annoura, Takeshi, Hensbergen, Paul J., Franke-Fayard, Blandine M., Barillas-Mury, Carolina, Scheeren, Ferenc A., Janse, Chris J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436314/ https://www.ncbi.nlm.nih.gov/pubmed/35994647 http://dx.doi.org/10.1073/pnas.2209729119

Ejemplares similares

Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites
por: Kolli, Surendra Kumar, et al.
Publicado: (2021)

A Novel ‘Gene Insertion/Marker Out’ (GIMO) Method for Transgene Expression and Gene Complementation in Rodent Malaria Parasites
por: Lin, Jing-wen, et al.
Publicado: (2011)

Soluble Variants of Human Recombinant Glutaminyl Cyclase
por: Castaldo, Cristiana, et al.
Publicado: (2013)

In vitro and in silico determination of glutaminyl cyclase inhibitors
por: Tran, Phuong-Thao, et al.
Publicado: (2019)

Generation of a Genetically Modified Chimeric Plasmodium falciparum Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Malaria Vaccine Development
por: Miyazaki, Yukiko, et al.
Publicado: (2020)

A genotyping assay to determine geographic origin and transmission potential of Plasmodium falciparum malaria cases
por: Molina-Cruz, Alvaro, et al.
Publicado: (2021)

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and target for cancer immunotherapy
por: Logtenberg, Meike E. W., et al.
Publicado: (2019)

Editorial: Malaria Targeting Toolkit: Host-Parasite Interactions
por: Araki, Tamasa, et al.
Publicado: (2021)

Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adaptation to different anopheline vectors
por: Molina-Cruz, Alvaro, et al.
Publicado: (2023)

Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase
por: Grant, Thomas D., et al.
Publicado: (2012)

A tracer-based method enables tracking of Plasmodium falciparum malaria parasites during human skin infection
por: Winkel, Béatrice M.F., et al.
Publicado: (2019)

Live In Vivo Imaging of Plasmodium Invasion of the Mosquito Midgut
por: Trisnadi, Nathanie, et al.
Publicado: (2020)

Generation of Novel Plasmodium falciparum NF135 and NF54 Lines Expressing Fluorescent Reporter Proteins Under the Control of Strong and Constitutive Promoters
por: Miyazaki, Shinya, et al.
Publicado: (2020)

Regulation of Plasmodium sporozoite motility by formulation components
por: de Korne, Clarize M., et al.
Publicado: (2019)

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
por: Cynis, Holger, et al.
Publicado: (2011)

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
por: Becker, Andreas, et al.
Publicado: (2013)

Identification of Glutaminyl Cyclase Genes Involved in Pyroglutamate Modification of Fungal Lignocellulolytic Enzymes
por: Wu, Vincent W., et al.
Publicado: (2017)

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2021)

Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells
por: Shang, Qi, et al.
Publicado: (2022)

The Bacteroidetes Q-rule and glutaminyl cyclase activity increase the stability of extracytoplasmic proteins
por: Szczęśniak, Katarzyna, et al.
Publicado: (2023)

Rapid Generation of Marker-Free P. falciparum Fluorescent Reporter Lines Using Modified CRISPR/Cas9 Constructs and Selection Protocol
por: Mogollon, Catherin Marin, et al.
Publicado: (2016)

The remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes
por: Molina-Cruz, Alvaro, et al.
Publicado: (2014)

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control
por: Gomes, Fabio M., et al.
Publicado: (2018)

Quantification of wild-type and radiation attenuated Plasmodium falciparum sporozoite motility in human skin
por: Winkel, Béatrice M. F., et al.
Publicado: (2019)

Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase
por: Ramsbeck, Daniel, et al.
Publicado: (2021)

Multimodal Tracking of Controlled Staphylococcus aureus Infections in Mice
por: Welling, Mick M., et al.
Publicado: (2019)

Evading resistance to gene drives
por: Gomulkiewicz, Richard, et al.
Publicado: (2021)

Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
por: Booth, Rachell E, et al.
Publicado: (2004)

Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy
por: Gillis, John Stuart
Publicado: (2006)

Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor
por: Guo, Li-Tao, et al.
Publicado: (2012)

Repurposing FDA‐Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease
por: Xu, Chenshu, et al.
Publicado: (2020)

Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
por: Franke-Fayard, Blandine, et al.
Publicado: (2022)

Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance
por: Lin, Jing-wen, et al.
Publicado: (2015)

Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate
Publicado: (1995)

Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors
por: Hielscher-Michael, Stephanie, et al.
Publicado: (2016)

The JNK Pathway Is a Key Mediator of Anopheles gambiae Antiplasmodial Immunity
por: Garver, Lindsey S., et al.
Publicado: (2013)

Molecular Analysis of Pfs47-Mediated Plasmodium Evasion of Mosquito Immunity
por: Canepa, Gaspar E., et al.
Publicado: (2016)

Reply to Patella et al. and Lindestam Arlehamn et al.: Complex pandemic dynamics and effect of bacillus Calmette–Guérin (BCG) vaccination on COVID-19 prevalence and mortality
por: Barillas-Mury, Carolina, et al.
Publicado: (2020)

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
por: Escobar, Luis E., et al.
Publicado: (2020)

Disturbed Ca(2+) Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer’s Disease In Vitro
por: De Kimpe, Line, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n1e15n68trbque65abl0im89p2