2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases

Premature termination codons (PTCs) account for 10 to 20% of genetic diseases in humans. The gene inactivation resulting from PTCs can be counteracted by the use of drugs stimulating PTC readthrough, thereby restoring production of the full-length protein. However, a greater chemical variety of read...

Descripción completa

Detalles Bibliográficos
Autores principales: Bidou, Laure, Bugaud, Olivier, Merer, Goulven, Coupet, Matthieu, Hatin, Isabelle, Chirkin, Egor, Karri, Sabrina, Demais, Stéphane, François, Pauline, Cintrat, Jean-Christophe, Namy, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436315/
https://www.ncbi.nlm.nih.gov/pubmed/35994666
http://dx.doi.org/10.1073/pnas.2122004119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436315/
https://www.ncbi.nlm.nih.gov/pubmed/35994666
http://dx.doi.org/10.1073/pnas.2122004119

Ejemplares similares