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2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases

Premature termination codons (PTCs) account for 10 to 20% of genetic diseases in humans. The gene inactivation resulting from PTCs can be counteracted by the use of drugs stimulating PTC readthrough, thereby restoring production of the full-length protein. However, a greater chemical variety of read...

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Detalles Bibliográficos
Autores principales:	Bidou, Laure, Bugaud, Olivier, Merer, Goulven, Coupet, Matthieu, Hatin, Isabelle, Chirkin, Egor, Karri, Sabrina, Demais, Stéphane, François, Pauline, Cintrat, Jean-Christophe, Namy, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436315/ https://www.ncbi.nlm.nih.gov/pubmed/35994666 http://dx.doi.org/10.1073/pnas.2122004119

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