TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with TPL2 mRNA

p38γ and p38δ (p38γ/p38δ) regulate inflammation, in part by controlling tumor progression locus 2 (TPL2) expression in myeloid cells. Here, we demonstrate that TPL2 protein levels are dramatically reduced in p38γ/p38δ-deficient (p38γ/δ(−/−)) cells and tissues without affecting TPL2 messenger ribonuc...

Descripción completa

Detalles Bibliográficos
Autores principales: Escós, Alejandra, Martín-Gómez, José, González-Romero, Diego, Díaz-Mora, Ester, Francisco-Velilla, Rosario, Santiago, Cesar, Cuezva, José M., Domínguez-Zorita, Sonia, Martínez-Salas, Encarnación, Sonenberg, Nahum, Sanz-Ezquerro, Juan José, Jafarnejad, Seyed Mehdi, Cuenda, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436348/
https://www.ncbi.nlm.nih.gov/pubmed/35994673
http://dx.doi.org/10.1073/pnas.2204752119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436348/
https://www.ncbi.nlm.nih.gov/pubmed/35994673
http://dx.doi.org/10.1073/pnas.2204752119

Ejemplares similares