Nucleotide excision repair removes thymidine analog 5-ethynyl-2′-deoxyuridine from the mammalian genome

Nucleotide excision repair is the principal mechanism for removing bulky DNA adducts from the mammalian genome, including those induced by environmental carcinogens such as UV radiation, and anticancer drugs such as cisplatin. Surprisingly, we found that the widely used thymidine analog EdU is a sub...

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Detalles Bibliográficos
Autores principales: Wang, Li, Cao, Xuemei, Yang, Yanyan, Kose, Cansu, Kawara, Hiroaki, Lindsey-Boltz, Laura A., Selby, Christopher P., Sancar, Aziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436350/
https://www.ncbi.nlm.nih.gov/pubmed/35994676
http://dx.doi.org/10.1073/pnas.2210176119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436350/
https://www.ncbi.nlm.nih.gov/pubmed/35994676
http://dx.doi.org/10.1073/pnas.2210176119

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