Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

Amyloid aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles is closely associated with Alzheimer’s disease (AD). Several molecular chaperones have been reported to bind Tau and impede its pathological aggregation. Recent findings of elevated levels of Hsp27 in the brains of patient...

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Detalles Bibliográficos
Autores principales: Zhang, Shengnan, Zhu, Yi, Lu, Jinxia, Liu, Zhenying, Lobato, Amanda G, Zeng, Wen, Liu, Jiaqi, Qiang, Jiali, Zeng, Shuyi, Zhang, Yaoyang, Liu, Cong, Liu, Jun, He, Zhuohao, Zhai, R Grace, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436411/
https://www.ncbi.nlm.nih.gov/pubmed/36048712
http://dx.doi.org/10.7554/eLife.79898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436411/
https://www.ncbi.nlm.nih.gov/pubmed/36048712
http://dx.doi.org/10.7554/eLife.79898

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