Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release

Repeated exposure to drugs of abuse results in an upregulation of cAMP signaling in the mesolimbic dopamine system, a molecular adaptation thought to be critically involved in the development of drug dependence. Exchange protein directly activated by cAMP (Epac2) is a major cAMP effector abundantly...

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Detalles Bibliográficos
Autores principales: Liu, Xiaojie, Vickstrom, Casey R, Yu, Hao, Liu, Shuai, Snarrenberg, Shana Terai, Friedman, Vladislav, Mu, Lianwei, Chen, Bixuan, Kelly, Thomas J, Baker, David A, Liu, Qing-song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436413/
https://www.ncbi.nlm.nih.gov/pubmed/35993549
http://dx.doi.org/10.7554/eLife.80747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436413/
https://www.ncbi.nlm.nih.gov/pubmed/35993549
http://dx.doi.org/10.7554/eLife.80747

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