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Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis
Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants. A total of 166 MDAAs with div...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436459/ https://www.ncbi.nlm.nih.gov/pubmed/36050566 http://dx.doi.org/10.1007/s13659-022-00355-y |
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author | Luo, Si-Yuan Zhu, Jun-Yu Zou, Ming-Feng Yin, Sheng Tang, Gui-Hua |
author_facet | Luo, Si-Yuan Zhu, Jun-Yu Zou, Ming-Feng Yin, Sheng Tang, Gui-Hua |
author_sort | Luo, Si-Yuan |
collection | PubMed |
description | Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants. A total of 166 MDAAs with diverse skeletons have been isolated and identified since 1980. Structurally, the classic MDAAs characterized by the chalcone-skeleton dienophiles can be divided into eight groups (Types A − H), while others with non-chalcone dienophiles or some variations of classic MDAAs are non-classic MDAAs (Type I). These compounds have attracted significant attention of natural products and synthetic chemists due to their complex architectures, remarkable biological activities, and synthetic challenges. The present review provides a comprehensive summary of the structural properties, bioactivities, and syntheses of MDAAs. Cited references were collected between 1980 and 2021 from the SciFinder, Web of Science, and China National Knowledge Internet (CNKI). GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-9436459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-94364592022-09-02 Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis Luo, Si-Yuan Zhu, Jun-Yu Zou, Ming-Feng Yin, Sheng Tang, Gui-Hua Nat Prod Bioprospect Review Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants. A total of 166 MDAAs with diverse skeletons have been isolated and identified since 1980. Structurally, the classic MDAAs characterized by the chalcone-skeleton dienophiles can be divided into eight groups (Types A − H), while others with non-chalcone dienophiles or some variations of classic MDAAs are non-classic MDAAs (Type I). These compounds have attracted significant attention of natural products and synthetic chemists due to their complex architectures, remarkable biological activities, and synthetic challenges. The present review provides a comprehensive summary of the structural properties, bioactivities, and syntheses of MDAAs. Cited references were collected between 1980 and 2021 from the SciFinder, Web of Science, and China National Knowledge Internet (CNKI). GRAPHICAL ABSTRACT: [Image: see text] Springer Nature Singapore 2022-09-02 /pmc/articles/PMC9436459/ /pubmed/36050566 http://dx.doi.org/10.1007/s13659-022-00355-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Luo, Si-Yuan Zhu, Jun-Yu Zou, Ming-Feng Yin, Sheng Tang, Gui-Hua Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis |
title | Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis |
title_full | Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis |
title_fullStr | Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis |
title_full_unstemmed | Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis |
title_short | Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis |
title_sort | mulberry diels–alder-type adducts: isolation, structure, bioactivity, and synthesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436459/ https://www.ncbi.nlm.nih.gov/pubmed/36050566 http://dx.doi.org/10.1007/s13659-022-00355-y |
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