Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks

PPM1D is a p53-regulated protein phosphatase that modulates the DNA damage response (DDR) and is frequently altered in cancer. Here, we employed chemical inhibition of PPM1D and quantitative mass spectrometry-based phosphoproteomics to identify the substrates of PPM1D upon induction of DNA double-st...

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Detalles Bibliográficos
Autores principales: Gräf, Justus F., Mikicic, Ivan, Ping, Xiaofei, Scalera, Claudia, Mayr, Katharina, Stelzl, Lukas S., Beli, Petra, Wagner, Sebastian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436757/
https://www.ncbi.nlm.nih.gov/pubmed/36060052
http://dx.doi.org/10.1016/j.isci.2022.104892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436757/
https://www.ncbi.nlm.nih.gov/pubmed/36060052
http://dx.doi.org/10.1016/j.isci.2022.104892

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