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L2Δ13, a splicing isoform of lysyl oxidase-like 2, causes adipose tissue loss via the gut microbiota and lipid metabolism

Obesity is primarily characterized by the dysregulation of lipid metabolism and gut microbiota. Here, we found that the body weight of transgenic mice overexpressing L2Δ13, a selectively spliced isoform of lysyl oxidase-like 2 (LOXL2), was lower than that of wild-type (WT) mice. Numerous microbiotas...

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Detalles Bibliográficos
Autores principales: Chen, Yang, He, Li-Xia, Chen, Jin-Ling, Xu, Xin, Wang, Juan-Juan, Zhan, Xiu-Hui, Jiao, Ji-Wei, Dong, Geng, Li, En-Min, Xu, Li-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436769/
https://www.ncbi.nlm.nih.gov/pubmed/36060061
http://dx.doi.org/10.1016/j.isci.2022.104894