Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2

Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting comorbid conditions like hypertension, diabetes, and obesity. We utilized the diet-induced obesity (DIO) model of metabolic dysfunction in K18-hACE2 transgenic mice to model obesity as a COVID-19 comorbidity. Female DIO...

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Detalles Bibliográficos
Autores principales: Lee, Katherine S., Russ, Brynnan P., Wong, Ting Y., Horspool, Alexander M., Winters, Michael T., Barbier, Mariette, Bevere, Justin R., Martinez, Ivan, Damron, F. Heath, Cyphert, Holly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436780/
https://www.ncbi.nlm.nih.gov/pubmed/36068847
http://dx.doi.org/10.1016/j.isci.2022.105038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436780/
https://www.ncbi.nlm.nih.gov/pubmed/36068847
http://dx.doi.org/10.1016/j.isci.2022.105038

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