The weaker-binding Fc γ receptor IIIa F158 allotype retains sensitivity to N-glycan composition and exhibits a destabilized antibody-binding interface

Antibodies engage Fc γ receptors (FcγRs) to elicit healing cellular immune responses following binding to a target antigen. Fc γ receptor IIIa/CD16a triggers natural killer cells to destroy target tissues with cytotoxic proteins and enhances phagocytosis mediated by macrophages. Multiple variables a...

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Detalles Bibliográficos
Autores principales: Kremer, Paul G., Barb, Adam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436803/
https://www.ncbi.nlm.nih.gov/pubmed/35921896
http://dx.doi.org/10.1016/j.jbc.2022.102329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436803/
https://www.ncbi.nlm.nih.gov/pubmed/35921896
http://dx.doi.org/10.1016/j.jbc.2022.102329

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