Cargando…

Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway

BACKGROUND: Mesangial cell proliferation is the most basic pathological feature of immunoglobulin A nephropathy (IgAN); however, the specific underlying mechanism and an appropriate therapeutic strategy are yet to be unearthed. This study aimed to investigate the therapeutic effect of triptolide (TP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Lu, Lan, Zhixin, Peng, Liang, Wan, Lili, Liu, Di, Tan, Xia, Tang, Chengyuan, Chen, Guochun, Liu, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436901/ https://www.ncbi.nlm.nih.gov/pubmed/35733381 http://dx.doi.org/10.1111/cpr.13278

Ejemplares similares

SUMO1 Promotes Mesangial Cell Proliferation Through Inhibiting Autophagy in a Cell Model of IgA Nephropathy
por: Tan, Xia, et al.
Publicado: (2022)

Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy
por: Nihei, Yoshihito, et al.
Publicado: (2023)

Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy
por: Wada, Yukihiro, et al.
Publicado: (2018)

Mesangial cells from patients with IgA nephropathy have increased susceptibility to galactose-deficient IgA1
por: Ebefors, Kerstin, et al.
Publicado: (2016)

Clinical significance of IgG deposition in the glomerular mesangial area in patients with IgA nephropathy
por: Wada, Yukihiro, et al.
Publicado: (2012)

Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy
por: Gan, Lu, et al.
Publicado: (2018)

Based on Network Pharmacology Tools to Investigate the Mechanism of Tripterygium wilfordii Against IgA Nephropathy
por: Xia, Ming, et al.
Publicado: (2021)

Downregulation of miR‑214-3p attenuates mesangial hypercellularity by targeting PTEN‑mediated JNK/c-Jun signaling in IgA nephropathy
por: Li, Yan, et al.
Publicado: (2021)

Role of Mononuclear Cells of IgA Nephropathy on ICAM-1 Expression in Mesangial Cells
por: Lee, Tae-Won, et al.
Publicado: (1998)

Gut-kidney axis in IgA nephropathy: Role on mesangial cell metabolism and inflammation
por: Luvizotto, Mateus Justi, et al.
Publicado: (2022)

Efficacy and indications of tonsillectomy in patients with IgA nephropathy: a retrospective study
por: Li, Yan, et al.
Publicado: (2022)

Tumor Necrosis Factor α from Peripheral Blood Mononuclear Cells of IgA Nephropathy and Mesangial Cell Proliferation
por: Lee, Tae-Won, et al.
Publicado: (1994)

p38 MAPK activity is associated with the histological degree of interstitial fibrosis in IgA nephropathy patients
por: Lee, Jeonghwan, et al.
Publicado: (2019)

Identification of Hub Genes and Therapeutic Agents for IgA Nephropathy Through Bioinformatics Analysis and Experimental Validation
por: Xia, Ming, et al.
Publicado: (2022)

Sialylation of IgG inhibits the formation of galactose-deficient IgA1-containing immune complexes and protects mesangial cells from injury in IgA nephropathy
por: Liu, Youxia, et al.
Publicado: (2022)

Tonsillectomy reduces recurrence of IgA nephropathy in mesangial hypercellularity type categorized by the Oxford classification
por: Hirano, Keita, et al.
Publicado: (2015)

Tetrandrine inhibits the proliferation of mesangial cells induced by enzymatically deglycosylated human IgA1 via IgA receptor/MAPK/NF-κB signaling pathway
por: Xu, Wencheng, et al.
Publicado: (2023)

RhoA vesicle trafficking–mediated transglutaminase 2 membrane translocation promotes IgA1 mesangial deposition in IgA nephropathy
por: Zhong, Zhong, et al.
Publicado: (2023)

Factors associated with the progression of mesangial lesions in IgA nephropathy: A comparative analysis of renal re-biopsies
por: Li, Yetong, et al.
Publicado: (2022)

Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls
por: Wang, Changsong, et al.
Publicado: (2015)

Clinicopathologic and Prognostic Study of Primary IgA Nephropathy With Light Chain λ Restriction in the Mesangial Deposits
por: Zhang, Ji, et al.
Publicado: (2022)

Distribution pattern of mesangial C4d deposits as predictor of kidney failure in IgA nephropathy
por: Worawichawong, Suchin, et al.
Publicado: (2021)

CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy
por: Lu, Guoyuan, et al.
Publicado: (2017)

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway
por: Han, Fei, et al.
Publicado: (2017)

IgA1 dominant subclass of latent IgA mesangial deposition in donated kidney
por: Oka, Kazumasa, et al.
Publicado: (2016)

Network Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of Tripterygium wilfordii (Lév.) Hutch Against IgA Nephropathy
por: Zhao, Juanyong, et al.
Publicado: (2023)

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum
por: Han, Fei, et al.
Publicado: (2020)

The Role of IgA in the Pathogenesis of IgA Nephropathy
por: Perše, Martina, et al.
Publicado: (2019)

Synergistic Effect of Mesangial Cell-Induced CXCL1 and TGF-β1 in Promoting Podocyte Loss in IgA Nephropathy
por: Zhu, Li, et al.
Publicado: (2013)

IgA Vasculitis and IgA Nephropathy: Same Disease?
por: Pillebout, Evangeline
Publicado: (2021)

Dimeric and polymeric IgA, but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells
por: Reterink, T. J. F., et al.
Publicado: (1996)

IgA nephropathy with leucocytoclastic vasculitis
por: Wei, Lin-Yan, et al.
Publicado: (2018)

Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy
por: Liang, Shikai, et al.
Publicado: (2018)

Experimental IgA nephropathy
Publicado: (1979)

Sulodexide in IgA nephropathy
Publicado: (2013)

T lymphocytes in IgA nephropathy
por: Tang, Yuyan, et al.
Publicado: (2020)

Decreased Circulating C3 Levels and Mesangial C3 Deposition Predict Renal Outcome in Patients with IgA Nephropathy
por: Kim, Seung Jun, et al.
Publicado: (2012)

Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells
por: Wu, Jingkui, et al.
Publicado: (2022)

Mesangial Cell–Derived Exosomal miR-4455 Induces Podocyte Injury in IgA Nephropathy by Targeting ULK2
por: Yu, Mengjie, et al.
Publicado: (2022)

Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy
por: Wang, Manliu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9se5pa2hfpshd2ljs65uejuqkg