The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells

This study aimed to synthesize new thioderivative chalcones and analyze their impact on the NF-κB, STAT3, EGFR and Nrf2 signaling pathways in colorectal cancer cells. Among the studied compounds, derivatives 4 and 5 decreased the activation of NF-κB and the expression of the target gene COX-2. In th...

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Detalles Bibliográficos
Autores principales: Papierska, Katarzyna, Krajka-Kuźniak, Violetta, Kleszcz, Robert, Stefański, Tomasz, Kurczab, Rafał, Kubicki, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436958/
https://www.ncbi.nlm.nih.gov/pubmed/36050500
http://dx.doi.org/10.1038/s41598-022-18981-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436958/
https://www.ncbi.nlm.nih.gov/pubmed/36050500
http://dx.doi.org/10.1038/s41598-022-18981-4

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