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Dietary 7-ketocholesterol exacerbates myocardial ischemia–reperfusion injury in mice through monocyte/macrophage-mediated inflammation

Emerging evidence suggests that 7-ketocholesterol (7-KC), one of the most abundant dietary oxysterols, causes inflammation and cardiovascular diseases. Here we show the deteriorating effects of dietary 7-KC on myocardial ischemia–reperfusion (IR) injury and detailed the molecular mechanisms. A high-...

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Detalles Bibliográficos
Autores principales: Uchikawa, Tomoki, Matoba, Tetsuya, Kawahara, Takuro, Baba, Isashi, Katsuki, Shunsuke, Koga, Jun-ichiro, Hashimoto, Yu, Yamasaki, Ryo, Ichi, Ikuyo, Akita, Hidetaka, Tsutsui, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436973/
https://www.ncbi.nlm.nih.gov/pubmed/36050346
http://dx.doi.org/10.1038/s41598-022-19065-z